Sunday, December 18, 2011

Russian fishing ship lists badly near Antarctica (AP)

WELLINGTON, New Zealand ? A Russian fishing vessel with 32 crew members was taking on water near Antarctica on Friday, and the nearest ship able to cut through the region's heavy sea ice was four or five days away.

The Sparta was listing at 13 degrees next to the Antarctic ice shelf in the Ross Sea, according to Maritime New Zealand. The agency said the crew was throwing cargo overboard to lighten the ship and some had boarded lifeboats as a precaution.

The ship has a 1-foot (30 centimeter) hole in the hull about 5 feet (1.5 meters) below the water line, the agency said. The crew so far had managed to pump out much of the incoming water and had attached a tarpaulin over the outside of the hole to slow the water flooding in, the agency said.

The crew have asked for more pumps to be sent to them and will try and make repairs to the hull, the agency said, adding it was trying to figure out a way to deliver the pumps.

"It's a very remote, unforgiving environment," said Andrew Wright, executive secretary of the Australian-based Commission for the Conservation of Antarctic Marine Living Resources, which has licensed the Sparta to catch toothfish in the Southern Ocean.

Wright said he didn't know what caused the hole, although he added an iceberg "would be a good candidate."

The Sparta, which is 157 feet (48 meters) long, sent a distress call early Friday. Maritime New Zealand said heavy ice in the Southern Ocean would make it difficult for other ships to reach the vessel.

The Sparta's sister ship Chiyo Maru No. 3 was 290 nautical miles away and heading toward the stricken vessel but had no capacity to cut through sea ice, the agency said. A New Zealand vessel, the San Aspiring, had some ice-cutting ability and was also en route, but was four or five days away. A third vessel was just 19 nautical miles away, but it was hemmed in by heavy ice and unable to move toward the Sparta.

Ramon Davis, who is coordinating rescue efforts for Maritime New Zealand, said a C-130 Hercules plane that arrived from Antarctica flew over the scene to assess ice conditions in the area to speed up the rescue efforts. But Davis said the aircraft would not be able to pick up the crew.

Davis said there were no helicopters in the area and that another vessel remained the most viable option for trying to rescue the crew.

"It is possible the crew will have a fairly long wait for rescue," he said.

He said that if the crew manage to lighten the ship enough by getting rid of cargo and pumping out water, it's possible the hole in the hull would rise above the water line.

The crew has some emergency immersion suits that could keep them alive for a time in freezing water, Maritime New Zealand said.

The weather in the area was calm, with temperatures a relatively mild 37 degrees Fahrenheit (3 degrees Celsius).

Commission records list the captain of the Sparta, which was built in 1988, as Oleg Pavlovich Starolat, who is Russian.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20111216/ap_on_re_as/as_new_zealand_stricken_ship

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No brakes on breast cancer cells

Friday, December 16, 2011

MicroRNAs or miRNAs are tiny RNA molecules that have only about 20 nucleotides and do not code for proteins. They regulate many important processes in cells by binding to target messenger RNAs ? the instructions for protein production ?, thus blocking production of the respective protein. In cancer, the production of some miRNAs is often reduced or amplified. This particularly affects miRNAs that regulate the activity of cancer-promoting genes.

A key molecule in the development of cancer is a transcription factor called NFkappaB, which is an important switch for many genes with inflammation-promoting effects. At DKFZ, Professor Dr. Stefan Wiemann and collaborators have now investigated whether microRNAs that affect NFkappaB production are deregulated in breast cancer. Jointly with colleagues at Heidelberg and Tuebingen University Hospitals, the DKFZ team studied over 800 miRNAs and discovered a family of RNA molecules known as miR-520, which particularly strongly reduce the production of NFkappaB. "If the cells produce less NFkappaB, the production of inflammation-promoting signaling molecules is reduced. This puts a brake on cancer growth, because these signaling molecules promote invasive capacity, formation of new vessels and metastasis," says Ioanna Keklikoglou, a doctoral student Wiemann's department, explaining this mechanism.

However, miR-520 does not only act like a cancer brake by suppressing NFkappaB. In addition, Wiemann's team discovered that this microRNA also blocks another cancer-promoting signaling pathway that is triggered by growth factor TGF-beta. TGF-beta signals cause malignant cells to be less firmly anchored in the tissue and, thus, better able to invade surrounding organs ? a characteristic feature of cancer cells.

Subsequently, the DKFZ researchers studied the question of whether the findings obtained in cancer cells in the culture dish are also involved in breast cancer. Studying tumor tissue samples of 76 patients, the team discovered that tumors which have already spread to the lymph nodes produce less miR-520 than those which have not yet spread. However, this connection was only found in tumors that do not produce receptors for the female sexual hormone, estrogen (ER-negative tumors).

"Our findings clearly demonstrate that miR-520 is a genuine cancer brake that suppresses the malignant behavior of tumor cells in two different ways at once," said Stefan Wiemann, commenting on the findings reported in his now published work. "This cancer brake appears to fail in many ER-negative breast tumors ? and also in cells of other types of cancer, as colleagues have now demonstrated." ER-negative breast cancer is particularly difficult to treat in many cases. Developing a microRNA therapy that blocks several cancer-promoting signaling pathways at once may therefore be an interesting option.

###

I Keklikoglou, C Koerner, C Schmidt, JD Zhang, D Heckmann, A Shavinskaya, H Allgayer, B G?ckel, T Fehm, A Schneeweiss, ? Sahin, S Wiemann and U Tschulena: MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-kappaB and TGF-b signaling pathways. Oncogene 2011, DOI: 10.1038/onc.2011.571

Helmholtz Association of German Research Centres: http://www.helmholtz.de/en/index.html

Thanks to Helmholtz Association of German Research Centres for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/116107/No_brakes_on_breast_cancer_cells

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Saturday, December 17, 2011

With Final Pre-Caucus Debate Looming, Unpredictable Iowa Race Could Have More Surprises in Store (ABC News)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/174899315?client_source=feed&format=rss

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Toshiba Thrive 7? Review: Cute, But Clunky

Toshiba Thrive 7"While the 7-inch Toshiba Thrive is much more comfortable in the hand than its 10-inch counterpart, many of the best features in big brother never migrated over to the 7-incher. That said, this still may be the slate for you if gaming and web-surfing take precedence over e-reading. Otherwise, I'd point you to the Amazon Kindle Fire.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/OdNhflGlkiM/

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Samsung: 25 million phones with Carrier IQ; other devices have 'dormant' code

Samsung Mobile

Samsung Mobile, in its response to U.S. Sen. Al Franken over the Carrier IQ saga, says that it's sold some 25 million cell phones preloaded with Carrier IQ software, which it's been using since 2007. Many of these phones are non-Android feature phones, and Samsung repeats the response we've already heard from HTC in that it's not a customer of Carrier IQ, therefore it doesn't see the data collected.

Interestingly, Samsung also echoes HTC by saying some of its phones also may contain components of Carrier IQ and therefore may trigger the various CIQ detector apps available, but that the software is "dormant." Unlike HTC, however, Samsung did not say whether it was working to remove these dormant components. Says Samsung:

"Because the CIQ agent and other required CIQ software components are not installed, however, these vestigial elements do not and will not function on these devices, and therefore, the devices do not transmit (and never have transmitted) any user data using any CIQ software functionality."

Samsung did not say which phones contain the dormant CIQ code.

Following are the Android smartphones Samsung says contain Carrier IQ:

  • AT&T: Samsung Galaxy S II Skyrocket
  • Sprint: Moment, Epic 4G, Intercept, Transform, Galaxy Tab (original 7-inch), Galaxy Prevail, Replenish, Conquer 4G, Transform Ultra (Boost Mobile), Epic 4G Touch
  • T-Mobile: Samsung Galaxy S II, Exhibit II 4G

More: Samsung's response (pdf)



Source: http://feedproxy.google.com/~r/androidcentral/~3/F9G0rg5Df0A/story01.htm

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Aiming To Be The ?Groupon Of Groceries?, SavingStar Passes 1 Million Users In Under A Year

Screen shot 2011-12-15 at 9.54.51 AMIt's been a pretty good ride so far for digital couponing startup SavingStar. The company launched its beta last August behind $2.3 million in financing from Flybridge Capital Partners, First Round Capital, and Founder Collective, with participation from angel investors like Ron Conway.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/Mt5vlIrG9-0/

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Friday, December 16, 2011

Timeline: 'The greatest thing Facebook's ever done'? (The Week)

New York ? For better or worse, Facebook's new profile lays out a user's entire online history in an easy-to-graze chronological format

It's here: After a September preview, Facebook is now rolling out its dramatic profile redesign ? Timeline ??to its 800-million-plus global users (watch a video tutorial here). The "entirely new kind of profile" collects every moment and detail of a users' life, every status update and post, and organizes the material in chronological order. One commentator likens it to "an obsessive compulsive's digital scrapbook." User can opt in to the upgrade and enjoy a 7-day review period before their new profile is made public, or simply wait until Facebook switches over all old profiles, which it plans to do. Another commentator calls Timeline "the greatest thing Facebook's ever done." Is it really?

Timeline is truly impressive: "This is the single greatest change that Facebook's ever pushed on us," says Sam Biddle at Gizmodo. Facebook now has the potential to provide a visual history of an entire life, from birth to this morning's breakfast. And, it's easy-to-use and unexpectedly "beautiful" given Facebook's typically lacklustre design. Sure, "there's a certain element of lost control" with Timeline and it's "a little messy ??but hey, so's life." This is an exciting, "enormous leap for social networking."
"Facebook Timeline review: This is the greatest thing Facebook's ever done"

And seductive: "From what I've seen so far, it's a solid update," says Don Reisinger at CNET. While some users are likely to balk at such a big change, it's easy to customize and set privacy controls, it looks good, and it allows you to get to know people even better online. After making the switch to Timeline myself, I was "immediately hit with a sense of nostalgia," seeing all my old photos and updates. For better or worse, it's all there.
"Facebook Timeline goes live ? out with old, in with new"

But it's also a bit of a pain: Facebook's big change may necessitate that users "do some privacy housekeeping," says Kashmir Hill at Forbes. "Many people, when building their networks, weren?t thinking about the information that would be exposed years after." It's a good idea to limit sharing to friends, and to unfriend people whom you don't really care about or want knowing all about your past.
"As Facebook Timeline rolls out, find out how well you know your friends"

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Source: http://us.rd.yahoo.com/dailynews/rss/oped/*http%3A//news.yahoo.com/s/theweek/20111215/cm_theweek/222525

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