Friday, January 20, 2012

MIND Reviews: The Better Angels of Our Nature

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The Better Angels of Our Nature: Why Violence Has Declined
by Steven Pinker. Viking Adult, 2011

According to the Stockholm International Peace Research Institute (SIPRI), worldwide military expenditures have been growing annually for the past 15 years, and between 15 and 20 major armed conflicts?yes, wars?are in progress as you read this. All told, upward of 175 million people died in war-related violence during the 20th century, plus another eight million because of conflicts among individuals.

Even so, according to this weighty new book by Harvard University psychologist Steven Pinker, the ?better angels? of human nature have actually brought about a dramatic reduction in violence during the past few millennia. Yes, the absolute number of victims has been rising, but relative to the world?s population, the numbers look good.

The shift toward nonviolence, he says, has been driven by many factors, such as the spread of agriculture and the rise of feminism and democracy. Such trends have led to a reduction in institutionalized torture and execution and slavery and, especially in recent years, to an increase in the rights of women, homosexuals, children and animals.

Pinker acknowledges that one?s immediate experience belies these facts to the point where you might even want to call him ?hallucinatory.? Yet the wealth of data he presents cannot be ignored?unless, that is, you take the same liberties as he sometimes does in his book. In two lengthy chapters, Pinker describes psychological processes that make us either violent or peaceful, respectively. Our dark side is driven by a evolution-based propensity toward predation and dominance. On the angelic side, we have, or at least can learn, some degree of self-control, which allows us to inhibit dark tendencies.

There is, however, another psychological process?confirmation bias?that Pinker sometimes succumbs to in his book. People pay more attention to facts that match their beliefs than those that undermine them. Pinker wants peace, and he also believes in his hypothesis; it is no surprise that he focuses more on facts that support his views than on those that do not. The SIPRI arms data are problematic, and a reader can also cherry-pick facts from Pinker?s own book that are inconsistent with his position. He notes, for example, that during the 20th century homicide rates failed to decline in both the U.S. and England. He also describes in graphic and disturbing detail the savage way in which chimpanzees?our closest genetic relatives in the animal world?torture and kill their own kind.

Of greater concern is the assumption on which Pinker?s entire case rests: that we look at relative numbers instead of absolute numbers in assessing human violence. But why should we be content with only a relative decrease? By this logic, when we reach a world population of nine billion in 2050, Pinker will conceivably be satisfied if a mere two million people are killed in war that year.

The biggest problem with the book, though, is its overreliance on history, which, like the light on a caboose, shows us only where we are not going. We live in a time when all the rules are being rewritten blindingly fast?when, for example, an increasingly smaller number of people can do increasingly greater damage. Yes, when you move from the Stone Age to modern times, some violence is left behind, but what happens when you put weapons of mass destruction into the hands of modern people who in many ways are still living primitively? What happens when the unprecedented occurs?when a country such as Iran, where women are still waiting for even the slightest glimpse of those better angels, obtains nuclear weapons? Pinker doesn?t say.


Source: http://rss.sciam.com/click.phdo?i=31212654dde227ce60b41702aecaa003

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thetecheye: Holmes and the missing Google billion - Or the strange case of "No Schmidt, Sherlock" http://t.co/S3Hzk8Li #mobile

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Source: http://twitter.com/thetecheye/statuses/159623152652136449

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Thursday, January 19, 2012

'Survivor: One World' cast revealed: Ex-NFL player's wife, swimsuit photographer and more

'Survivor: One World' cast revealed: Ex-NFL player's wife, swimsuit photographer and more Zap2it

11:54 a.m. MST, January 18, 2012

CBS has announced the 18 castaways who will be competing on "Survivor: One World," which premieres Wednesday, Feb. 15 at 8 p.m. ET/PT on CBS.

In this 24th season of the popular reality competition show, the castaways will be on two different tribes (men vs. women) but will live on the same beach, where they'll have to decide just how much of their resources and intel they want to share with the other tribe.


The tribes are named Salani and Manono, named after islands in Samoa. Here are the 18 castaways:

Salani

Nina Acosta????????????????????????????????????????????????????????????
Age: 51????????????????????????????????????????????????????????????????????
Current Residence: Clovis, Calif.???????????????????
Occupation: Retired LAPD Officer???

Monica Culpepper*
Age: 41
Current residence: Tampa, Fla.
Occupation: Ex-NFL player's wife ??

Kate Edorsson
Age: 22
Current residence: Orlando, Fla.
Occupation: Timeshare rep ??

Chelsea Meissner
Age: 26
Current residence: Charleston, S.C.

Source: http://feedproxy.google.com/~r/kdvr-entertainment/~3/RIY_ihKxLG8/zap-survivor-one-world-cast-revealed-ex-nfl-player-20120118,0,6894770.story

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Huntsman departure a marginal help to Romney in SC (AP)

COLUMBIA, S.C. ? Republican Jon Huntsman's endorsement of Mitt Romney further cements Romney as the favorite in Saturday's pivotal South Carolina primary, adding another name to the list of party figures calling him best able to beat Democratic President Bararck Obama.

However, it leaves Romney's more conservative rivals still fighting with one another to emerge as his strongest challenger. And it prompted at least one backer of Texas Gov. Rick Perry to urge him to quit the race.

Besides offering Romney his support, Huntsman also appealed for civility in a race that has become defined by attack advertisements paid for by anonymous groups.

"At its core, the Republican Party is a party of ideas, but the current toxic form of our political discourse does not help our cause," he said, as televisions and telephones across the state hummed with attack messages.

Huntsman's endorsement offers little in the way of a campaign organization or bankable support to Romney.

But it does add to the sense of inevitability the former Massachusetts governor has worked to portray in a state that has voted for the eventual GOP since 1980 and where he is campaigning with backing from the state's new Gov. Nikki Haley and Arizona Sen. John McCain, winner of the 2008 primary here.

Romney stands a good chance of winning the votes Huntsman would have received. Both tout business backgrounds and are social moderates in a state where social conservatives are an influential bloc. Polls show Romney was most often the second choice of Huntsman backers.

"Certainly, it will help Gov. Romney here, it's just not clear how much," said former state Attorney General Henry McMaster. An early Huntsman supporter, McMaster had not committed to another candidate after Huntsman's announcement.

But Huntsman's leaves unanswered the overriding question of the Republican campaign: whether voters looking for a candidate more conservative than Romney will unite behind Rick Santorum, Newt Gingrich or Perry and send a strong challenger to compete against Romney in the Florida primary or beyond.

Santorum, a former Pennsylvania senator, dismissed the endorsement during a campaign stop at a Columbia restaurant. "Moderates are backing moderates," he said. "No surprise there."

Gingrich, the former House speaker locked in a bitter battle with Romney, said at an appearance in Myrtle Beach: "Why would you want to nominate the guy who lost to the guy who lost to Obama?"

Gingrich also quickly noted late Sunday, as news of Huntsman's decision broke, that a Greenville businesswoman who had supported the former Utah governor was coming over to Gingrich.

Although Huntsman's departure hardly assures Romney of victory in Saturday's primary, it underscored the tension within the party's conservative wing with just five days left for one of them to emerge.

Santorum was the consensus, if not unanimous, choice of a group of national Christian political activists who met over the weekend in a last-ditch effort to rally conservatives.

"I think it's important that we eventually consolidate this race," Santorum said, stopping short of saying pressure was building on Perry to drop out. "That's up to the candidates themselves to decide."

Polls in South Carolina showed Romney in the lead, followed by Gingrich with Santorum and Texas Rep. Ron Paul fighting for third. Perry trailed in single digits.

A few of Perry's backers have begun calling on him to leave the race.

"There are a lot of conservatives who were happy to see him get in and now who would be happy to see him get out," state Rep. Larry Grooms, an early Perry supporter, told The Associated Press. "When conservatives have split in the past, we end up nominating a moderate, and that's not good for our party."

Conservative author Eric Metaxas indirectly suggested Perry should quit the race while speaking at a packed prayer breakfast in Myrtle Beach on Sunday. The night before he had tweeted: "Dear Gov. Perry: Do the right thing for your country; endorse Rick Santorum before the SC Primary next Saturday...you'll wish you had."

Some South Carolina Republicans still rue McCain's narrow 2008 win over the more socially conservative Mike Huckabee, allowed largely by former Tennessee Sen. Fred Thompson's decision to stay in the race.

Katon Dawson, Perry's South Carolina chairman, resisted the idea that there was a drumbeat for Perry to quit. "I find it sort of offensive that some Republicans would tell us they want to hand pick the candidate before the election," Dawson said.

Ralph Reed, founder of the national Faith and Freedom Coalition, also said he knew of no effort by the conservative leaders who met Saturday in Texas to urge Perry to quit.

"We have never asked any candidate to drop out of the race publicly or privately. And we will not do so," Reed said.

Some evangelical pastors and conservative leaders in Iowa had asked Minnesota Rep. Michele Bachmann to consider ending her campaign to allow a conservative to emerge. She did not, and Romney edged Santorum in Iowa by a razor-thin eight votes.

With Perry showing no signs of departing, Santorum faces the added burden of a barrage of attack ads by an independent super PAC that supports Romney's campaign.

The group, Restore Our Future, was running almost $900,000 worth of advertising this week, more than any of the candidates' campaigns and all of it against Santorum.

Santorum complained Monday about the ads, which accuse him of having supported earmark spending in Congress and supporting voting rights for felons.

Santorum has defended his support for earmark spending. He said Monday he supports allowing felons who have completed their sentences to apply to have their voting rights restored, a policy that is law in 48 states.

Restore Our Future spent roughly $3 million on similar anti-Gingrich ads in the final month of the Iowa campaign and was seen as contributing to his fourth-place finish in the caucuses.

A similar group that supports Gingrich was running roughly $850,000 in ads against Romney.

___

Hunt reported from Myrtle Beach, S.C. Associated Press writer Shannon McCaffrey in Myrtle Beach, S.C., contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/politics/*http%3A//news.yahoo.com/s/ap/20120116/ap_on_el_pr/us_romney_huntsman

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Wednesday, January 18, 2012

Some breast cancer spread may be triggered by a protein, study shows

Tuesday, January 17, 2012

Cancers rarely are deadly unless they evolve the ability to grow beyond the tissues in which they first arise. Normally, cells -- even early-stage tumor cells -- are tethered to scaffolding that helps to restrain any destructive tendencies. But scientists from the University of Helsinki, Finland, and from UCSF have identified a cleaver-wielding protein that frees some tumor cells, allowing them to further misbehave.

The protein, they discovered, often blankets the surface of breast tumor cells and can help untether the cells from the matrix of their native tissue. Once released, they may continue to expand their numbers into other tissues where their normal counterparts do not tread.

The protein, called hepsin, is a protease, a class of enzymes that cleaves, or cuts, other proteins. Proteases have been targeted successfully by drugs, and hepsin presents a new possible drug target, the researchers said.

"If we could delay or prevent a tumor from switching from one that grows in place to one that invades, then that would be a major milestone in cancer treatment," said study co-author Zena Werb, PhD, a professor of anatomy at UCSF. Werb has for decades studied the ways in which the behavior of tumor cells is influenced by their surroundings, with a focus on breast tumors.

Working with mouse models of breast development and breast cancer in Werb's UCSF laboratory during a visiting professorship, University of Helsinki scientist Juha Klefstr?m, PhD -- along with Johanna Partanen, a University of Helsinki graduate student -- designed and led experiments that resulted in the discovery of the hepsin protein's role.

Their findings are published in the January 16, 2012 edition of the Proceedings of the American Academy of Sciences (PNAS).

The scientists studied mammary glands in mice and tissue fragments ? called organoids ? isolated from these glands.

They found that inactivation of a tumor suppressor gene known as liver kinase B1 (Lkb1) caused abnormal development of parts of the mammary gland, including milk-secreting structures. Specifically, they determined that a tightly knit matrix of protein fibers called the basement membrane -- which normally surrounds the milk-secreting structures -- was damaged and degraded.

These events may be triggered in many tumors, the team said, as they found that Lkb1 was abnormally missing in 1 out of every 4 human breast cancer samples they looked at.

Most solid tumors arise from "epithelial" cells, which line the surfaces and cavities of organs. The basement membrane, in turn, lines epithelial cell layers in tissues.

In their mouse studies, the researchers quickly settled on hepsin as a suspect in the destruction of the basement membrane that in turn allows tumor cells to become unbound. In the absence of Lkb1, the protein-cleaving enzyme was abnormally spread over the cell surface. They found that deactivating hepsin allowed the basement membrane to recover.

Graduate student Partanen sought to recapitulate the development of cancer by re-engineering the mice, knocking Lkb1 out of normal mammary epithelial cells. Again, hepsin spread abnormally and basement membrane proteins were sliced and diced. After a year, though, she found that the mice had not grown mammary tumors.

"I was disappointed with the results," she said. "However, then I realized that although broken basement membrane may give cells more freedom to proliferate, the cells may just lay there, resting, and not start to over-proliferate unless they are pushed into cycles of cell division."

Partanen then re-engineered the mice so that they also abnormally activated a gene called Myc, which, is known to help initiate tumors in many tissues, including breast epithelium. She soon saw the mice begin to form tumors.

"We found in our study that genetic removal of hepsin from the mammary gland organoids prevents formation of cancerous tissue," Klefstr?m said. "This finding excites us, as it leads us to think that inhibition of hepsin by drug-like molecules could restrain cancer progression.

"However, we do not know yet if we can cure already-formed tumors by blocking hepsin activity. We need to first improve our experimental systems to properly address this question."

According to Web, "We have observed that loss of Lkb1, combined with activation of a weak inducer of breast cancer ? an oncogene such as Myc ? can produce aggressive cancers.

"In humans, breast cancers that have diminished amounts of Lkb1 show strong hepsin expression. Since hepsin sits on the cell membrane, it should be accessible to drugs. We believe that hepsin forms a novel target for treatment of a subset of breast cancer patients."

###

University of California - San Francisco: http://www.ucsf.edu

Thanks to University of California - San Francisco for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/116749/Some_breast_cancer_spread_may_be_triggered_by_a_protein__study_shows

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House Speaker Lujan has lung cancer

SANTA FE, N.M. (AP) - House Speaker Ben Lujan has lung cancer and will not seek re-election this year, the 76-year-old announced Tuesday in a dramatic opening of a 30-day legislative session.

The Santa Fe Democrat, who has been speaker since 2001, made his announcement as shocked lawmakers wept and his wife, Carmen, and son, Democratic Congressman Ben Ray Lujan, looked on.

Lujan said he was diagnosed with cancer in 2009 and has undergone radiation and chemotherapy treatment. He said his cancer is now at stage 4, the most advanced stage of cancer.

"I was hoping to tell you the cancer is gone, but as you can see, it is not," said Lujan, who has served in the House since 1975.

After Lujan made the announcement, lawmakers gave the speaker a standing ovation. Carmen Lujan wept as a long line of lawmaker and well-known political figures gathered to offer their thoughts and prayers to the family.

Ben Lujan was the House's majority whip and majority floor leader before being elected speaker. He succeeded longtime Speaker Raymond Sanchez, who lost his seat in the Legislature in 2000.

"While this has taken a toll on me physically, it has not broken my spirit, my will, my faith and my commitment to New Mexico," said Ben Lujan.

The speaker survived a challenge to his speakership last year when Rep. Joe Cervantes, D-Las Cruces, sought his seat.

Source: http://www.krqe.com/dpp/news/politics/house-speaker-lujan-has-lung-cancer

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Tuesday, January 17, 2012

Championship pedigree shows for Brady, Eli

New England Patriots quarterback Tom Brady signals to his bench during the second half of an NFL divisional playoff football game against the Denver Broncos Saturday, Jan. 14, 2012, in Foxborough, Mass. (AP Photo/Elise Amendola)

New England Patriots quarterback Tom Brady signals to his bench during the second half of an NFL divisional playoff football game against the Denver Broncos Saturday, Jan. 14, 2012, in Foxborough, Mass. (AP Photo/Elise Amendola)

New England Patriots quarterback Tom Brady (12) congratulates New England Patriots wide receiver Wes Welker after Welker scored on a seven yard touchdown pass during the first half of an NFL divisional playoff football game against the Denver Broncos Saturday, Jan. 14, 2012, in Foxborough, Mass. (AP Photo/Charles Krupa)

New York Giants quarterback Eli Manning runs onto the field before an NFL divisional playoff football game against the Green Bay Packers Sunday, Jan. 15, 2012, in Green Bay, Wis. (AP Photo/Jeffrey Phelps)

New York Giants quarterback Eli Manning throws a pass during the first the first half of an NFL divisional playoff football game against the Green Bay Packers Sunday, Jan. 15, 2012, in Green Bay, Wis. (AP Photo/Jeffrey Phelps)

San Francisco 49ers quarterback Alex Smith (11) reacts after scoring a touchdown against the New Orleans Saints in the fourth quarter of an NFL divisional playoff football game Saturday, Jan. 14, 2012, in San Francisco. (AP Photo/Marcio Jose Sanchez)

The playoffs have a way of bringing out the pedigree in NFL quarterbacks. Simply take a look at the fingers of Tom Brady and Eli Manning to recognize it.

Brady has three Super Bowl rings, with another taken away by Manning and the Giants in 2008. Both have their teams on course for a reprise of that memorable title game.

Standing in their way are two inconsistent QBs seeking to fill out their own championship resumes: Joe Flacco of Baltimore and Alex Smith of San Francisco.

Based on their histories and the way they have performed this season, Brady and Manning overmatch Flacco and Smith. When things have gotten tight for New England or New York, the quarterback often has provided the winning edge.

"The team revolves around him," Patriots tight end Aaron Hernandez said of Brady. "When he comes to play, which he mostly does every game, then we're going to be on fire, and when he's ready, we're all ready."

Ditto for Manning. Even when the Giants hit a four-game slide that jeopardized making the playoffs, he stood out.

"He's just been great," said receiver Victor Cruz, who had a breakout season with Manning throwing to him. "He understands the defense, he understands what we can see on every single down and every single coverage and he's just making the right reads and really hitting people when the time is right."

The time certainly is right. For a decade, it's been Brady time once New Year's Day hits. In early 2008, it also was Manning time.

It is again.

Brady was as good as ever in Saturday's romp past outmanned Denver. His six TD passes tied Steve Young and Daryle Lamonica for the NFL record. His five in one half were the most ever.

Sure, he's got superb targets in All-Pros Wes Welker at wideout and Rob Gronkowski at tight end, plus Hernandez and Deion Branch, who is something of a security blanket for Brady. He also makes them outstanding with his precise passes, leadership and competitiveness.

It rubs off.

"We never look at the individual. We all try and do our job," defensive tackle Vince Wilfork said. "If (Brady) plays well, everyone else plays well. When he has an off day, we try to rally around him as a team to help Tom and the offense. We aren't going to get 20-30 points all the time."

Thirty certainly could be difficult against Baltimore's staunch defense. But 20 might be enough if Flacco doesn't come through.

Something of a surprise first-round draft choice in 2008 out of Delaware, he's helped the Ravens make the playoffs in all four of his NFL seasons. In great part, Flacco has been along for the ride as opposed to driving the vehicle the way Brady does.

He also doesn't have nearly the talent to throw to, with the exception of running back Ray Rice, who led the NFL with 2,068 total yards. His offensive line is spotty.

For Baltimore to reach its first Super Bowl since 2001 ? oh, yeah, the QB then was Trent Dilfer, and Flacco is a far better player than Dilfer was ? some of Brady has to rub off on Flacco.

Smith finally has become comfortable in San Francisco thanks to new coach Jim Harbaugh's guidance and confidence in the seven-year veteran. The 49ers are efficient on offense with a strong running game behind Frank Gore, and a tight end, Vernon Davis, who displayed all his skills in a sensational playoff debut against New Orleans.

To expect Smith to trade throws with Saints star Drew Brees was unthinkable, yet there he was, making clutch pass after clutch pass in the late stages of Saturday's thrilling win. If he's capable of a similar performance against the Giants, it would enhance San Francisco's chances immeasurably.

"He deserves all this," Gore said of Smith's revival. "He's had some tough times. But I always believed he could play at this level. We have the right people leading us. And he's got the right people leading him."

Leading the 49ers to the Super Bowl means beating Manning and the Giants. The Niners did it in November when Smith made just enough key plays. That's been his style this season, a style Manning once adhered to.

Now, Manning is as much a playmaker as his older brother, Peyton, has been. Or as Brady is.

Indeed, another title will give him the championship lead in his family, adding yet another shiny achievement to Eli's resume. But he'd still be behind Brady.

For now, Smith and Flacco can only wonder if they have what it takes to grab the ring.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-01-16-FBN-On-Football-QB-Pedigree/id-96318fedacb54568bf60b8a633dea083

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